Short Intense Exercise Session Alters Blood Molecules Linked to Cancer Genes

Researchers have reported that a brief session of intense cycling exercise can alter molecules in the blood, with laboratory evidence showing effects on genes related to cancer cell activity.

The study, published in the International Journal of Cancer, involved 30 volunteers who were overweight or obese but otherwise healthy, aged between 50 and 78. Participants completed a single 10-minute session of vigorous cycling, after which blood samples were collected for analysis.

Analysis of the blood samples found that levels of 13 proteins, including interleukin-6 (IL-6), increased following the exercise session. The researchers then applied these post-exercise blood samples to bowel cancer cells in laboratory conditions to observe any changes in gene activity.

Laboratory testing revealed that more than 1,300 genes in the cancer cells showed altered activity after exposure to the exercise-conditioned blood. These genes included those involved in DNA repair, energy production, and cell growth processes.

What the numbers show

• 30 volunteers aged 50–78 participated in the study
• 13 proteins increased in blood after exercise
• More than 1,300 genes in cancer cells affected by post-exercise serum

The researchers found that the blood collected after exercise enhanced DNA repair mechanisms and reduced activity in genes associated with rapid cell division in cancer cells. This suggests a molecular link between physical activity and changes in cancer-related gene expression.

Dr. Sam Orange, a senior lecturer in clinical exercise physiology at Newcastle University, led the study and stated that even a single 10-minute workout can send signals through the bloodstream that influence gene activity in cancer cells. Multiple media outlets, including NDTV and ScienceAlert, reported on the findings and described similar molecular effects following brief, intense exercise.

ScienceAlert reported that the study showed exercise-induced molecules in the blood can speed up DNA repair and reduce the activity of genes related to cancer growth. The study provides a potential mechanistic explanation for how physical activity may lower bowel cancer risk by influencing gene expression linked to tumors.

These findings contribute to ongoing research into the biological effects of exercise, particularly in relation to cancer prevention and the molecular pathways involved in tumor development.

* This article is based on publicly available information at the time of writing.